ELAGOLIX SODIUM for endometriosis
Elagolix sodium is an approved GnRH receptor antagonist indicated for endometriosis per Open Targets annotation.
Hypothesized mechanism
By antagonizing the gonadotropin-releasing hormone receptor, elagolix suppresses gonadotropin and downstream estrogen production, reducing estrogen-driven endometriotic lesion activity.
This is the model’s proposed mechanism from the sources on file, not a demonstrated causal pathway. How well the published record supports it is reflected in the rigor and plausibility dimensions of the score, and traced to the verbatim sources at the foot of the page.
How the score was reached, for this pair
The composite score is the sum of five dimensions, each scored 0 to 2 by the model from the evidence on file. Below is the sub-score this specific pair received on each, with what that dimension measures. It scored 4.5 of 10 overall, a emerging reading, from a pathway rated emerging in strength.
The model’s overall reasoning for this pair is the summary at the top of the page, and the mechanism it proposed is in the section above.
Scored for women. Female representation not stated — applicability to women uncertain (flagged for full text). (band F4, ×0.75).
Corroboration
Only a single line of evidence is provided: an Open Targets annotation that elagolix sodium is a GnRH receptor antagonist approved for endometriosis. No independent mechanistic studies or converging pathways are cited.
Rigor
The claim derives from a curated database (Open Targets) reflecting an approved clinical-stage drug, which implies human-relevant evidence, but no actual model, trial, or experimental data is shown to gauge strength or recency.
Specificity
The claim explicitly names the drug's mechanism as a Gonadotropin-releasing hormone receptor antagonist acting on the GnRH receptor target, indicating a well-defined and specific drug-target interaction.
Plausibility
GnRH receptor antagonism suppresses estrogen production, directly fitting the estrogen-dependent pathophysiology of endometriosis; the drug is listed at maximum clinical stage APPROVAL, supporting strong target-phenotype fit.
Consistency
The single claim is internally consistent (antagonist mechanism appropriate for the condition), but with only one signal there is no opportunity to assess agreement across multiple mechanistic lines.
Layers not covered for this pair
Not covered for this pair. This layer holds documented sex-specific pharmacokinetics for a limited set of drugs, and this compound is not among them yet. A blank here means the drug is not covered by the layer, not that no sex difference exists.
More on the sex-specific pharmacokinetics layer and its sources →Not covered for this pair. The cycle-phase layer is seeded for the strongest-evidence cases so far (PMDD), and this pair is not among them yet. A blank here means the pair is not covered by the layer, not that the effect was found to be phase-independent.
More on the cycle-phase layer and its sources →Source evidence · what the pipeline ingested
These are the sources the pipeline ingested to detect and score this signal, the published literature the model actually read, each tagged by study type. Where the model combined findings the claim is marked as a synthesis (S), and where the literature disagrees the contradiction is shown (!).
Every source below belongs to this signal’s evidence arm, Pathway insights. Whel reads each drug-condition pair through four such arms, each held to its own inclusion bar; a signal is surfaced through one of them.
- 1Per Open Targets (retrieved 2026-06-16), ELAGOLIX SODIUM (a Small molecule) is a clinical candidate for endometriosis (maximum clinical stage APPROVAL); its mechanism of action is Gonadotropin-releasing hormone receptor antagonist on target gonadotropin releasing hormone receptor. Open Targets · mechanistic ↗
These are the verbatim sources the pipeline surfaced and read; they may not be the full published record for a pair, and the score reflects the strength and agreement of the evidence rather than its volume. The strength of these source types is what the rigor dimension of the score reads off. MATRIX, sex-specific pharmacokinetics, and cycle phase are separate layers the pipeline does not ingest, external cross-references reported beside the score, and they link to their own sources in their sections above.
The primary sources and pipelines this evidence is drawn from →