lidocaine ointment for vulvodynia
A state-of-the-science review reports that overnight 5% lidocaine ointment has the highest level of evidence for vulvodynia, supported by at least one RCT or comparative effectiveness trial.
Hypothesized mechanism
Topical lidocaine acts as a local anesthetic, blocking sodium channels to reduce vulvar nociceptive pain.
This is the model’s proposed mechanism from the sources on file, not a demonstrated causal pathway. How well the published record supports it is reflected in the rigor and plausibility dimensions of the score, and traced to the verbatim sources at the foot of the page.
How the score was reached, for this pair
The composite score is the sum of five dimensions, each scored 0 to 2 by the model from the evidence on file. Below is the sub-score this specific pair received on each, with what that dimension measures. It scored 7 of 10 overall, a moderate reading, from a direct rated moderate in strength.
The model’s overall reasoning for this pair is the summary at the top of the page, and the mechanism it proposed is in the section above.
Scored for women. Evidence generated in women (female population, ~100% female). (band F1, ×1.00).
Corroboration
The single claim references at least one RCT or comparative effectiveness trial as the basis for lidocaine evidence, but cites only one review source describing this. There is no indication of multiple independent corroborating studies, so this remains at the level of a single synthesis/source.
Rigor
The claim explicitly states overnight 5% lidocaine ointment had 'at least one RCT or comparative effectiveness trial' for vulvodynia, indicating RCT-level evidence. This supports a high rigor score.
Specificity
Both the intervention (overnight 5% lidocaine ointment) and condition (vulvodynia) are named directly in the claim and quote. The match is exact.
Plausibility
Lidocaine is a topical anesthetic with a plausible mechanism for reducing vulvar pain, though no explicit mechanism is described in the claim. The mechanism is plausible but not evidenced in the text shown.
Consistency
Only a single source/claim is provided describing the evidence level, so directional agreement across studies cannot be assessed. Per convention, a single source is scored 1 (not penalized).
Layers not covered for this pair
Not covered for this pair. This layer holds documented sex-specific pharmacokinetics for a limited set of drugs, and this compound is not among them yet. A blank here means the drug is not covered by the layer, not that no sex difference exists.
More on the sex-specific pharmacokinetics layer and its sources →Not covered for this pair. The cycle-phase layer is seeded for the strongest-evidence cases so far (PMDD), and this pair is not among them yet. A blank here means the pair is not covered by the layer, not that the effect was found to be phase-independent.
More on the cycle-phase layer and its sources →Source evidence · what the pipeline ingested
These are the sources the pipeline ingested to detect and score this signal, the published literature the model actually read, each tagged by study type. Where the model combined findings the claim is marked as a synthesis (S), and where the literature disagrees the contradiction is shown (!).
Every source below belongs to this signal’s evidence arm, Direct research. Whel reads each drug-condition pair through four such arms, each held to its own inclusion bar; a signal is surfaced through one of them.
- 1overnight 5% lidocaine ointment, and acupuncture had the highest level of evidence with at least one RCT or comparative effectiveness trial. PubMed · PMID 36533637 ↗
These are the verbatim sources the pipeline surfaced and read; they may not be the full published record for a pair, and the score reflects the strength and agreement of the evidence rather than its volume. The strength of these source types is what the rigor dimension of the score reads off. MATRIX, sex-specific pharmacokinetics, and cycle phase are separate layers the pipeline does not ingest, external cross-references reported beside the score, and they link to their own sources in their sections above.
The primary sources and pipelines this evidence is drawn from →