DESVENLAFAXINE SUCCINATE for menopause
Desvenlafaxine succinate is a Phase 3 clinical candidate for menopause acting via serotonin transporter (SLC6A4) inhibition per Open Targets.
Hypothesized mechanism
Inhibition of the serotonin transporter (SLC6A4) increases synaptic serotonin, which may modulate hypothalamic thermoregulatory pathways underlying menopausal vasomotor symptoms.
This is the model’s proposed mechanism from the sources on file, not a demonstrated causal pathway. How well the published record supports it is reflected in the rigor and plausibility dimensions of the score, and traced to the verbatim sources at the foot of the page.
How the score was reached, for this pair
The composite score is the sum of five dimensions, each scored 0 to 2 by the model from the evidence on file. Below is the sub-score this specific pair received on each, with what that dimension measures. It scored 3.8 of 10 overall, a emerging reading, from a pathway rated emerging in strength.
The model’s overall reasoning for this pair is the summary at the top of the page, and the mechanism it proposed is in the section above.
Scored for women. Female representation not stated — applicability to women uncertain (flagged for full text). (band F4, ×0.75).
Corroboration
Only a single line of evidence is provided: an Open Targets database entry naming desvenlafaxine succinate as a serotonin transporter inhibitor and a Phase 3 candidate for menopause. No independent mechanistic studies converge to corroborate the pathway.
Rigor
The claim cites a curated database entry (Open Targets) noting a maximum clinical stage of Phase 3, implying human clinical development, which is human-relevant. However, no actual study models, data, or mechanistic experiments are presented—only a target-disease association annotation.
Specificity
The claim specifies a precise mechanism—serotonin transporter (SLC6A4) inhibition—which is a well-defined molecular target for desvenlafaxine. This is a highly specific drug-target action statement.
Plausibility
Serotonin transporter inhibition is mechanistically plausible for vasomotor menopausal symptoms, and the Phase 3 status supports target-phenotype fit. However, the single claim does not articulate how SERT inhibition links to the menopause phenotype beyond the database association.
Consistency
There is only one mechanistic signal (SERT inhibition), so directionality cannot be cross-checked against other lines. The single statement is internally consistent but provides no convergence to assess.
Layers not covered for this pair
Not covered for this pair. This layer holds documented sex-specific pharmacokinetics for a limited set of drugs, and this compound is not among them yet. A blank here means the drug is not covered by the layer, not that no sex difference exists.
More on the sex-specific pharmacokinetics layer and its sources →Not covered for this pair. The cycle-phase layer is seeded for the strongest-evidence cases so far (PMDD), and this pair is not among them yet. A blank here means the pair is not covered by the layer, not that the effect was found to be phase-independent.
More on the cycle-phase layer and its sources →Source evidence · what the pipeline ingested
These are the sources the pipeline ingested to detect and score this signal, the published literature the model actually read, each tagged by study type. Where the model combined findings the claim is marked as a synthesis (S), and where the literature disagrees the contradiction is shown (!).
Every source below belongs to this signal’s evidence arm, Pathway insights. Whel reads each drug-condition pair through four such arms, each held to its own inclusion bar; a signal is surfaced through one of them.
- 1Per Open Targets (retrieved 2026-06-16), DESVENLAFAXINE SUCCINATE (a Small molecule) is a clinical candidate for menopause (maximum clinical stage PHASE_3); its mechanism of action is Serotonin transporter inhibitor on target solute carrier family 6 member 4. Open Targets · mechanistic ↗
- 2In FDA AEMS (the FDA Adverse Event Reporting System, formerly FAERS; retrieved 2026-06-16), 1142 report(s) of INSOMNIA were recorded for DESVENLAFAXINE SUCCINATE among female patients (of 18271 female reports for DESVENLAFAXINE SUCCINATE in the analysed sample). This is a raw adverse-event report count, not a disproportionality statistic or evidence of causation, and is subject to reporting bias and confounding. Read two ways: as a safety consideration, and — because it suggests DESVENLAFAXINE SUCCINATE acts on a system relevant to menopause — as a mechanistic lead for further investigation, not evidence of benefit. AEMS · adverse-event report ↗
- 3In FDA AEMS (the FDA Adverse Event Reporting System, formerly FAERS; retrieved 2026-06-16), 540 report(s) of HYPERHIDROSIS were recorded for DESVENLAFAXINE SUCCINATE among female patients (of 18271 female reports for DESVENLAFAXINE SUCCINATE in the analysed sample). This is a raw adverse-event report count, not a disproportionality statistic or evidence of causation, and is subject to reporting bias and confounding. Read two ways: as a safety consideration, and — because it suggests DESVENLAFAXINE SUCCINATE acts on a system relevant to menopause — as a mechanistic lead for further investigation, not evidence of benefit. AEMS · adverse-event report ↗
- 4In FDA AEMS (the FDA Adverse Event Reporting System, formerly FAERS; retrieved 2026-06-16), 173 report(s) of HOT FLUSH were recorded for DESVENLAFAXINE SUCCINATE among female patients (of 18271 female reports for DESVENLAFAXINE SUCCINATE in the analysed sample). This is a raw adverse-event report count, not a disproportionality statistic or evidence of causation, and is subject to reporting bias and confounding. Read two ways: as a safety consideration, and — because it suggests DESVENLAFAXINE SUCCINATE acts on a system relevant to menopause — as a mechanistic lead for further investigation, not evidence of benefit. AEMS · adverse-event report ↗
These are the verbatim sources the pipeline surfaced and read; they may not be the full published record for a pair, and the score reflects the strength and agreement of the evidence rather than its volume. The strength of these source types is what the rigor dimension of the score reads off. MATRIX, sex-specific pharmacokinetics, and cycle phase are separate layers the pipeline does not ingest, external cross-references reported beside the score, and they link to their own sources in their sections above.
The primary sources and pipelines this evidence is drawn from →